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KMID : 0361020010440050506
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 5 p.506 ~ p.511
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The Detection of Human Papillomavirus and Epstein-Barr Virus DNA in Maxillary Sinus Carcinoma by Polymerase Chain Reaction
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조재식/Jae Shik Cho
임상철/정형수/임회정/김정현/Sang Chul Lim/Hyeong Soo Jeong/Hoi Jeung Lim/Jeong Hyun Kim
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Abstract
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Objectives : Maxillary sinus carcinoma is rare when compared with cancers of other sites, and its etiology remains unknown. Recent reports demonstrate the possible etiologic role of human papillomavirus(HPV) and Epstein-Barr virus(EBV) in
maxillary
sinus carcinoma. The aim of this study is to detect HPV and EBV in the maxillary sinus carcinoma and examine the relationship between HPV, EBV and maxillary sinus carcinoma. We also compared the clinical features of patients with HPV-positive and
HPV-negative to determine the clinical significance of HPV. Materials and Method : The authors retrospectively searched for HPV and EBV in 40 cases of maxillary sinus carcinoma by using the polymerase chain reaction(PCR) on DNA extracted from
formalin-fixed, paraffin-embedded tissues. Results : HPV was detected in 5 of the 40 cases(12.5%) of maxillary sinus carcinoma, whose histological type was all squamous cell carcinoma. EBV was not detected. Among the five HPV-positives, three
were
HPV
subtype 16 and two were not determined. Conclusion : HPV may play a role in the pathogenesis of maxillary sinus carninoma, but EBV needs further study. However, the presence of HPV is not related to T-category, cervical metastases, or local
recurrence.
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KEYWORD
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